EFFECT OF n-PROPYL GALLATE ON THERMOTROPIC BEHAVIOUR OF LIPID MIXTURES WITH DIFFERENT DEGREE OF UNSATURATION IN PHOSPHATIDYLCHOLINE
نویسندگان
چکیده
Phosphatidylcholine/sphingomyelin/cholesterol (PC/SM/CHOL) ternary mixtures were investigated using differential scanning calorimetry (DSC). Palmitoyl-oleoyl phosphatidylcholine (POPC) and palmitoyl-docosahexaenoyl (-3) phosphatidylcholine (PDPC) were used to study the effect of the number of double bonds at the sn-2 position in PC molecule on the phase behavior of PC/SM/CHOL mixtures. The PDPC-containing mixture showed a lower cooperativity of the transition than the POPC mixture. Moreover, in the PDPC/SM/CHOL mixture more pronounced phase separation between the two co-existing phases was detected. The antioxidant n-propyl-gallate (nPG) exhibited a fluidizing effect on both types of mixtures. This thermotropic effect might be implicated in its mechanism of antioxidant protection.
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